Plg deficiency induces the hepatic expression of exocrine pancreatic genes during liver repair. (A and B) The high levels of expression of exocrine pancreatic genes exclusively at 14 days after toxic injury in Plgo livers as determined by the Affymetrix GeneChip (A) or PCR (B). tryp, trypsinogen; amy, amylase; elas, elastase; CE-Lip, cholesterol-ester lipase. (C) A zymographic analysis shows pancreas-specific amylase-2 (Amy-2) activity in livers of Plgo mice 14 days after CCl4 (and in normal pancreas as a positive control), whereas amylase-1 (Amy-1) activity is present in all liver samples and salivary gland tissue. The key indicates the Plg genotypes and whether CCl4 was administered to mice. Li, liver; Sg, salivary gland; Pn, pancreas.