Table 2. Anti-CSF114(Glc) IgM titers, but not IgG, in RR-MS patients are significantly increased compared with NBD and OAD.

	RR-MS	OAD	NBD	IND
IgM titers	943 ± 488*	467 ± 366	488 ± 504	999 ± 674*
IgM titers above cut-off	51 (21)	0 (0)	10 (6)	7 (27)
IgG titers	816 ± 814	400 ± 401	866 ± 872	854 ± 801
IgG titers above cut-off	65 (26)	3 (3)	36 (21)	9 (36)

Comparison of anti-CSF114(Glc) IgM and IgG mean titers in RR-MS patients (n = 250), OAD (n = 90), NBD (n = 166), and IND (n = 25). Values for IgM and IgG titers are means ± SD. IgM cut-off was set at the mean ± 2 SD of NBD. IgG cut-off was set at 1,000. Values in parentheses indicate percentages. ^*, P < 0.001 vs. NBD by Mann-Whitney U test.