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The dual APL down-regulates the expression of CD28. Cells (n = 106 per ml) of the line were stimulated with p195–212 (5 μg per ml) with or without the dual or the reversed dual APL (500 μg per ml). After 24 h, cells were stained with FITC-coupled anti-CD28 antibody and analyzed by FACS. Results are presented as the percentage of CD28 cells, and they represent one of two experiments performed.
