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The dual APL up-regulates regulatory markers on p195–212-specific T cells. Cells (n = 106 per ml) of the line were stimulated with p195–212 (5 μg per ml) with or without the dual or reversed dual APL (500 μg per ml) for 24 h. Cells were double-stained for CD25 and CD45Rb (A), intracellular CTLA-4 (B), intracellular TGF-β (C), or CD62L (D). The results in A are presented as the percentage of CD45Rblow gated as R2. Results represent one of two experiments performed.
