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. 2025 Jan 29;53(3):gkae1325. doi: 10.1093/nar/gkae1325

Figure 1.

Figure 1.

Adipose tissue and mitochondrial characterizations in Wbscr16 knockout mice and cells. (A) Representative western blots of WBSCR16 in iBAT, WAT and liver from floxed and AWBSCR16 KO mice were shown as indicated. Asterisks denote non-specific signals, and arrows indicate the band corresponding to WBSCR16. (B–D) Representative images and HE staining of iBAT (B), relative weight normalized to body weight (C) (n = 9–11), and cross-sectional area of LDs in iBAT (D) (n = 100) were shown. (E–G) Representative images and HE staining of WAT (E), relative weight normalized to body weight (F) and fat mass-to-lean mass ratio (G) (n = 10–15) were shown. (H–J) Electron microscopic images of iBAT (H), along with quantification of mitochondrial number (I) (n = 8) and size (J) (n = 52–68) in iBAT from floxed and AWBSCR16 KO mice were shown. (K) Representative western blots of WBSCR16 in overexpressed (OE) or knockout (KO) MEFs were shown. (L and M) Electron microscopic images of MEFs (L) and quantification of mitochondria size (M) (n = 31–42) in control, Wbscr16-OE, and KO cells were shown. Data were presented as mean ± SEM; t-test: *P < 0.05, **P < 0.01, ***P < 0.001.