Table 1.
Overview of Included SNPs
| dbSNP ID | Position (GRCh38) | Gene | Alleles | MAF SAGE | MAF Databasesa | HWE p-valueb | Protein Domain | References |
|---|---|---|---|---|---|---|---|---|
| rs279871 | 4:46303716 | GABRA2 | T/C | 0.439 | 0.425 | 0.257 | Intron variant | Association with subjective effects of alcohol,34–39 AUD,33,45,49,50,62 drinking prediction,63,64 and altered GABRA2 expression.65 |
| rs211014 | 5:162149412 | GABRG2 | C/A | 0.236 | 0.246 | 0.921 | Intron variant | Association with alcohol dependence,33,66,67 heroin dependence68 epileptic and febrile seizures.69–72 |
| rs3219151 | 5:161701908 | GABRA6 | C/A | 0.450 | 0.453 | 0.964 | 3 prime UTR-variant | Association with alcohol dependence,33 drinking quantity,73 AUD and GABRA6-expression65 and epilepsy.74 |
Notes: aMAF ALFA from https://www.ncbi.nlm.nih.gov/snp/. bPearson’s χ2- test.
Abbreviations: SNP, Single Nucleotide Polymorphism; GRCh38, Genome Reference Consortium Human Build 38; MAF, Minor Allele Frequency; SAGE, Susceptibility Addiction Gene Environment-cohort; HWE, Hardy Weinberg Equilibrium; AUD, Alcohol Use Disorder, UTR, Untranslated Region.