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. 1973 Jul;133(3):493–498. doi: 10.1042/bj1330493

The synthesis of esters of bilirubin

David W Hutchinson 1,*, Brian Johnson 1, Alan J Knell 1
PMCID: PMC1177726  PMID: 4733237

Abstract

1-Alkyl-3-p-tolytriazenes were used to synthesize the methyl, ethyl, isopropyl and benzyl esters of bilirubin. Treatment of a chloroform solution of bilirubin with the triazene at room temperature gave high yields of the corresponding esters. These were identified by n.m.r. and mass spectroscopy together with elemental analysis. N.m.r. studies also suggest that bilirubin dimethyl ester is in the lactam rather than the lactim form.

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Selected References

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