Fig. 3. Immune cell heterogeneity after T-VEC treatment.
a, UMAP of tumor cells and their microenvironment in post-treatment BCC samples (n = 102,093 cells) from a subset of patients (n = 12) by scRNA-seq analysis. A total of 18 cell clusters were identified and denoted by colors such as malignant cells, keratinocytes, fibroblasts, endothelial cells, melanocytes, three T cell subsets, NK cells, proliferating cells, B and plasma cells, pDCs, dendritic cells, LCs, mast cells and Mono-Mac, as well as a nondefined ‘other’ cluster. b, Bubble plot indicating the average (Avg.) expression of selected marker genes of the cell types in a.