Table 2.
Patient status and treatments administered at the time of enrolment and discharge.
| Control | LPV/r | p (vs. control) | DRV/r | p (vs. control) | |
|---|---|---|---|---|---|
| SaO2 (admission) | 95.2 ± 4.4 | 95 ± 5.7 | 0.86 | 94.6 ± 3.4 | 0.99 |
| Low SaO2 at admission (<90%) | 12 (8.6%) | 13 (9.4%) | 0.4 | 20 (14%) | 0.07 |
| SaO2 (discharge) | 95.4 ± 6.2 | 95.7 ± 5.7 | 0.92 | 94.8 ± 6.3 | 0.81 |
| Blood pressure admission (systole, mmHg) | 129.31 ± 18.79 | 128.48 ± 17.52 | 0.92 | 130.82 ± 19.54 | 0.77 |
| Blood pressure admission (diastole, mmHg) | 80.34 ± 12.35 | 80.52 ± 10.23 | 0.99 | 82.76 ± 12.47 | 0.2 |
| Heart rate admission | 84.86 ± 14.13 | 85.06 ± 14.55 | 0.99 | 87.46 ± 15.54 | 0.31 |
| Body temperature admission (°C) | 36.21 ± 2.85 | 36.57 ± 0.71 | 0.21 | 36.51 ± 0.65 | 0.33 |
| Blood pressure discharge (systole, mmHg) | 124.63 ± 15.63 | 125.43 ± 16.13 | 0.91 | 126.39 ± 18.79 | 0.66 |
| Blood pressure discharge(diastole, mmHg) | 78.58 ± 11.0 | 78.51 ± 10.56 | 0.99 | 80.01 ± 12.22 | 0.54 |
| Heart rate discharge | 79.52 ± 12.32 | 81.32 ± 13.78 | 0.51 | 80.67 ± 14.60 | 0.76 |
| Body temperature discharge (°C) | 36.32 ± 0.46 | 36.27 ± 0.46 | 0.97 | 36.31 ± 0.36 | 0.99 |
| Na (mmol/l) | 135.88 ± 3.95 | 136.98 ± 3.07 | 0.047 | 136.68 ± 4.16 | 0.14 |
| K (mmol/l) | 4.26 ± 0.63 | 4.12 ± 0.51 | 0.12 | 4.34 ± 0.65 | 0.71 |
| CRP (mg/ml) | 39.3 ± 59.2 | 37.5 ± 58.5 | 0.8 | 63.7 ± 88.6 | <0.01 |
| Glycaemia (admission) | 136.9 ± 79.8 | 136.7 ± 73.6 | 0.99 | 145.9 ± 73 | 0.55 |
| Impaired glucose >110 mg/dl | 54 (39%) | 67 (48%) | 0.065 | 87 (62.6%) | <0.01 |
| High glucose >125 mg/dl | 41 (29.5%) | 48 (34.5%) | 0.18 | 87 (62.6%) | <0.01 |
| Fibrinogen | 4.43 ± 1.48 | 4.52 ± 1.78 | 0.96 | 5.07 ± 4.2 | 0.14 |
| GOT (U/ml) | 27.98 ± 19.89 | 40.50 ± 71.31 | 0.76 | 59.61 ± 238.26 | 0.52 |
| GPT (U/ml) | 35.88 ± 36.65 | 68.84 ± 192.92 | 0.07 | 54.74 ± 66.17 | 0.41 |
| Oxygen therapy | 33 (23.7%) | 30 (21.6%) | 0.33 | 74 (53.2%) | <0.01 |
| Ceftriaxone | 34 (24.5) | 24 (17.3%) | 0.06 | 55 (39.6%) | <0.01 |
| Azithromycin | 56 (40.3%) | 58 (41.7%) | 0.4 | 68 (48.9%) | 0.07 |
| Dexamethasone | 58 (41.7%) | 59 (42.4%) | 0.45 | 116 (83.4%) | <0.01 |
| LMWH | 84 (60.4%) | 110 (79.1%) | <0.01 | 136 (97.8%) | <0.01 |
Data are expressed as number (percentage) or mean± standard deviation (SD). CRP, C-reactive protein; GOT, glutamate oxaloacetate transaminase; GPT, glutamate pyruvate transaminase; LMWH, Low molecular weight heparin; SaO2, arterial oxygen saturation.