Table 2.
Transepithelial resistance, LDH release and PAO1 binding to 16HBEo- cell lines.
| Sense | AntiSense | |||||
| Resistance (Ω*cm2) | LDH (u) | GFP-PA01 (RFU) | Resistance (Ω*cm2) | LDH (u) | GFP-PA01 (RFU) | |
| PA alone | 229.0 ± 13.8 | 4.08 ± 0.4 | 0.6056 ± 0.078 | 217.85 ± 8.0 | 2.12 ± 0.2* | 0.5753 ± 0.021 |
| PA + EGTA | 136.14 ± 6.1 | 2.42 ± 0.3 | ND | 142.43 ± 5.9 | 2.78 ± 0.6 | ND |
| PA + ECAD | 126.0 ± 2.3 | 2.95 ± 0.3 | ND | 131.0 ± 1.3 | 2.99 ± 0.4 | ND |
| PA + aGM1 | ND | ND | 0.6456 ± 0.051 | ND | ND | 0.7437 ± 0.165† |
| PA + C.p. | ND | ND | 0.5851 ± 0.031 | ND | ND | 0.5154 ± 0.031 |
| No treatment | 316.54 ± 10.5 | 4.31 ± 0.7 | ND | 225.72 ± 2.9 | 1.24 ± 0.1* | ND |
| EGTA alone | 213.58 ± 15.2 | 3.22 ± 0.0 | ND | 202.4 ± 4.3 | 0.86 ± 0.0 | ND |
| ECAD alone | 147.186 ± 14.4 | 3.73 ± 0.0 | ND | 151.09 ± 6.2 | 1.07 ± 0.2 | ND |
* Different from Sense congener, p < 0.05
†Different from no aGM1, p < 0.05