Figure 3.

B. burgdorferi infection induces production of RF that is in part dependent on the presence of the autoantigen. (A) Ratios of serum RF levels between day 30 and day 0 in infected mice compared with controls. Each point represents an individual mouse and the relative level of RF at day 30 compared with the day 0 level. Open symbols, uninfected; filled symbols, infected. *P < 0.05, Mann-Whitney test. (B) Kinetic of mean RF levels between day 0 and day of sacrifice in Hul × cIgG infected mice, compared with Smi × cIgG infected mice. **P < 0.005 compared with day 0 level, Mann-Whitney test.