TABLE 7.
Top 10 most frequent and central keywords in BRAF and MEK inhibitor resistance research in melanoma.
| Rank | Keyword | Counts | Rank | Keyword | Counts |
|---|---|---|---|---|---|
| 1 | Acquired-resistance | 748 | 11 | Mechanisms | 225 |
| 2 | Mutations | 513 | 12 | Growth | 213 |
| 3 | Survival | 461 | 13 | Drug resistance | 178 |
| 4 | Activation | 424 | 14 | Mapk pathway | 171 |
| 5 | Open-label | 411 | 15 | Cutaneous melanoma | 170 |
| 6 | Pathway | 349 | 16 | Combination | 151 |
| 7 | Targeted therapy | 331 | 17 | Ipilimumab | 151 |
| 8 | Apoptosis | 266 | 18 | Braf inhibitors | 138 |
| 9 | Improved survival | 261 | 19 | Raf inhibitors | 138 |
| 10 | Immunotherapy | 249 | 20 | Progression | 135 |