Table 1.
Comparation of clinical parameters, cognitive function preference and IL-5 levels between control and MCI group in patients with T2DM
| Control (n = 70) | MCI (n = 35) | P | |
|---|---|---|---|
| Age (year) | 55.50 (49.00, 59.00) | 59.00 (54.00, 65.00) | 0.004b* |
| Female (n, %) | 20, 28.57 | 19, 54.29 | 0.010c* |
| Education | 12.00 (9.00, 15.00) | 12.00 (6.00, 12.00) | 0.118b |
| BMI (Kg/m2) | 24.99 (22.25, 27.05) | 24.24 (22.50, 25.98) | 0.605b |
| HbA1c (%) | 8.61 ± 1.85 | 8.70 ± 1.35 | 0.807a |
| FPG | 7.58 (5.95, 10.02) | 7.21 (5.82, 8.94) | 0.373b |
| C peptide | 517.97 (96.95, 692.04) | 414.73 (292.12, 589.00) | 0.210b |
| TG (mmol/l) | 1.43 (1.00, 2.24) | 1.49 (0.79, 2.36) | 0.765b |
| TC (mmol/l) | 3.96 (3.52, 4.94) | 4.35 (3.33, 5.36) | 0.552b |
| HDL-C (mmol/l) | 0.97 (0.85, 1.16) | 1.01 (0.90, 1.20) | 0.386b |
| LDL-C (mmol/l) | 2.72 ± 0.82 | 2.72 ± 0.75 | 0.965a |
| IL-5 (pg/ml) | 22.21 ± 2.57 | 23.89 ± 1.87 | 0.001a* |
| MoCA | 28.00 (27.00, 28.00) | 23.00 (21.00, 25.00) | 0.000b* |
| DST | 11.00 (10.00, 13.00) | 10.00 (9.00, 12.00) | 0.009b* |
| VFT | 18.00 (16.00, 21.00) | 14.00 (12.00, 17.00) | 0.000b* |
| TMTA | 53.50 (42.50, 70.25) | 75.00 (55.00, 102.00) | 0.000b* |
| TMTB | 137.50 (112.25, 175.00) | 183.00 (143.00, 258.00) | 0.000b* |
| LMT | 9.00 (6.00, 13.25) | 8.00 (4.00, 12.00) | 0.096b |
Notes:
a Student’s t test was employed for normally distributed variables
b The Mann-Whitney U test was employed for asymmetrically distributed variables
c The Chi-square test was employed for categorical variables
*P < 0.05
Abbreviations: IL-5, interleukin-5; MCI, mild cognitive impairment; BMI, body mass index; HbA1c, glycosylated hemoglobin; FPG, fasting plasma glucose; TG, triglycerides; TC, Total cholesterol; LDL-C, low density lipoprotein cholesterol; HDL-C, high density lipoprotein cholesterol; MoCA, Montreal Cognitive Assessment; DST, Digit Span Test; VFT, Verbal Fluency Test; TMTA, Trail Making Test-A; TMTB, Trail Making Test-B; LMT, Logical memory test