Table 3.

Comparison of adjusted for aggressive SBT (pressure support 7 cm H₂O or pressure support 8 cm H₂O + 5 cm H₂O PEEP) diagnostic accuracy for reintubation at 7 days of the three models including 2341 patients recruited in five randomized trials [11, 12, 14, 15, 19]

	Se	Sp	PPV	NPV	Youden	Kappa
3 Factors model	90.37%	17.56%	18.65%	89.71%	0.08	0.03
4 Factors model	93.33%	13.58%	18.43%	90.69%	0.07	0.03
11 Factors model	96.05%	10.18%	18.28%	92.49%	0.06	0.02

Se sensitivity; Sp specificity; PPV positive predictive value; NPV negative predictive value

The 3-factors model included the following risk factors: age > 65y, chronic heart or pulmonary disease. The 4-factors model included the following risk factors: age > 65y, chronic heart or pulmonary disease, and prolonged mechanical ventilation. The 11-factors model included the following risk factors: age > 65 years, ≥ 2 comorbidities, prolonged mechanical ventilation, acute heart failure as the primary indication for mechanical ventilation, moderate-to-severe chronic obstructive pulmonary disease, APACHE II score > 12 on extubation day, airway patency problems, inability to deal with respiratory secretions, not simple weaning, obesity, or hypercapnia at the end of the spontaneous breathing trial