Table 1.
Baseline characteristics of the patients treated with Y-90 SIRT (N = 52).
| Characteristics | Value |
|---|---|
| Age (years) | 64.9 ± 11.1 |
| Male, n (%) | 42 (81) |
| Etiology of cirrhosis, n (%) | |
| Hepatitis B virus infection | 23 (44) |
| Non-alcoholic fatty liver disease | 9 (17) |
| Hepatitis C virus infection | 7 (13) |
| Alcoholic cirrhosis | 6 (12) |
| Cryptogenic | 6 (12) |
| Non-cirrhosis | 1 (2) |
| Child-Pugh class, n (%) | |
| A | 45 (86) |
| B7 | 5 (10) |
| B8 | 1 (2) |
| B9 | 1 (2) |
| ECOG, n (%) | |
| 0 | 26 (50) |
| 1 | 25 (48) |
| 2 | 1 (2) |
| Liver function | |
| Total bilirubin (mg/dL) | 0.83 (0.23–2.18) |
| Albumin (g/dL) | 3.7 (2.6–4.4) |
| AFP, n (%) | |
| <200 ng/mL | 23 (46) |
| ≥200 ng/mL | 27 (54) |
| Distribution of HCC, n (%) | |
| Bilobar | 25 (48) |
| Unilobar | 27 (52) |
| Number of lesions, n (%) | |
| Single | 7 (13) |
| 2–3 | 8 (15) |
| Multifocal | 37 (71) |
| Maximum size, n (%) | |
| <5 cm | 8 (15) |
| 5–10 cm | 22 (42) |
| >10 cm | 9 (17) |
| Infiltrative lesion | 13 (25) |
| Portal vein thrombosis, n (%) | |
| Absent | 19 (37) |
| Main branch | 13 (25) |
| Segmental branch | 20 (38) |
| BCLC stage, n (%) | |
| B | 15 (29) |
| C | 37 (71) |
| Prior treatment, n (%)a | |
| None | 22 (42) |
| TACE alone | 10 (19) |
| TACE with othersb | 16 (31) |
| Others without TACEc | 4 (8) |
Data were expressed as the mean ± standard deviation or median (range).
Abbreviations: AFP, alpha-fetoprotein; BCLC, Barcelona Clinic Liver Cancer; EBRT, external beam radiation therapy; ECOG, Eastern Cooperative Oncology Group; HCC, hepatocellular carcinoma; RFA, radiofrequency ablation; TACE, transarterial chemoembolization.
Most patients received more than one treatment as follows: cTACE (n = 26), resection (n = 9), RFA (n = 7), EBRT (n = 6), systemic therapy with sorafenib or nivolumab (n = 5), drug-eluting beads TACE (n = 2), and liver transplantation (n = 1).
TACE with others: TACE with RFA (n = 5), resection (n = 2), systemic therapy (n = 1), drug eluting beads (n = 1), EBRT and systemic therapy (n = 3), resection and EBRT (n = 2), resection and systemic therapy (n = 1), resection and RFA (n = 1).
Others without TACE: resection (n = 1), resection with EBRT (n = 1), RFA (n = 1), EBRT (n = 1).