Table 7. List of up and down-regulated genes with their gene ontologies and KEGG annotations.

Gene Ontology
-	Up Regulating Genes	Activity	Down-Regulating Genes	Activity
Biological Process	KIF2C, KIF11, BUB1B, NUSAP1, KIF20A, CEP55, CDK1, TOP2A, CCNA2, HMMR, ASPM, DLGAP5, TPX2, NCAPG CENPF, BUB1, MELK, TTK, CCNB2	Cell cycle process,      Mitotic cell division,      Nuclear division,      Cell division,      Organelle fission	AFM,      PON1,      HPX,      TAT,      HGR,      FGB	Wound healing,      blood,      hemostasis,      external encapsulating structure
Cellular Components		Microtubule cytoskeleton,      Spindle,      Supramolecular complex		Regulation of body fluids,      collagen containing extracellular matrix
Molecular Function		ATP binding,   Adenyl ribonucleotide   Nucleotide binding		Signaling receptor binding complement
KEGG Pathway
Pathways	BUB1, BUB1B, CCNA2, CCNB2, CDK1, TTK,	Cell cycle,   Oocyte meiosis,   Progesterone mediated oocyte maturation   P53 signaling pathway   Cellular senescence   Viral carcinogenesis	TAT, FGB	Ubiquinone and other terpenoid-quinone biosynthesis coagulation cascade PPAR signaling pathway