TABLE II.

Univariate and Multivariate Cox Regression for Exploring the Association of CHA₂DS₂-VASc Score and Prognosis at 12 Months in the Population Before and After PSM

Variable	CHA2DS2-VASc	Before PSM						After PSM
		Univariate analysis			Multivariate analysis			Univariate analysis			Multivariate analysis
		HR	95% CI	P value	HR	95% CI	P value	HR	95% CI	P value	HR	95% CI	P value
MACE	Continuous	1.21	1.15-1.27	<.01	1.19	1.11-1.26	<.01	1.12	1.03-1.21	<.01	1.13	1.04-1.23	<.01
	Categorical
	Low risk	[Reference]			[Reference]			[Reference]			[Reference]
	Moderate risk	1.70	1.16-2.49	<.01	1.92	1.24-2.98	<.01	1.78	1.13-2.82	.01	1.76	1.11-2.80	.02
	High risk	2.71	1.97-3.72	<.01	3.22	1.93-5.37	<.01	2.14	1.36-3.36	<.01	2.10	1.32-3.34	<.01
All-cause mortality	Continuous	1.17	1.10-1.25	<.01	1.14	1.05-1.23	<.01	1.13	1.02-1.25	.02	1.15	1.03-1.28	.01
	Categorical
	Low risk	[Reference]			[Reference]			[Reference]			[Reference]
	Moderate risk	1.75	1.08-2.82	.02	2.04	1.18-3.53	.01	1.73	0.95-3.17	.07	1.70	0.92-3.12	.09
	High risk	2.78	1.87-4.14	<.01	3.47	1.84-6.56	<.01	2.42	1.36-4.31	<.01	2.50	1.38-4.51	<.01
Recurrent stroke	Continuous	1.17	1.10-1.25	<.01	1.15	1.06-1.25	<.01	1.11	1.01-1.22	.02	1.12	1.01-1.23	.03
	Categorical
	Low risk	[Reference]			[Reference]			[Reference]			[Reference]
	Moderate risk	1.85	1.16-2.95	<.01	1.87	1.10-3.20	.02	2.27	1.33-3.85	<.01	2.31	1.35-3.94	<.01
	High risk	2.35	1.57-3.50	<.01	2.39	1.25-4.56	<.01	2.46	1.45-4.19	<.01	2.44	1.41-4.21	<.01

CHA₂DS₂-VASc, congestive heart failure, hypertension, age ≥75 years, diabetes mellitus, prior stroke or transient ischemic attack, vascular disease, age 65-74 years, and female sex; HR, hazard ratio; MACE, major adverse cardiovascular event; PSM, propensity score matching.

P < .05 was considered statistically significant.