Table 4. IOP Decreasing Effects of CAIs in Albino and Pigmented Rabbitsa.
| compound | AUC0-last ± SD in albino rabbits (mmHg x h) | AUC0-last ± SD in pigmented rabbits (mmHg × h) | ratio (AUCpigm/AUCalbino) |
|---|---|---|---|
| dorzolamide | 15.55 ± 10.64 | 202.351 ± 122.60 | 13.0 |
| A01 | 19.95 ± 7.16 | 1704.902 ± 530.82 | 85.5 |
| A12 | 13.80 ± 10.06 | 124.653 ± 79.15 | 9.0 |
| A22 | 10.50 ± 8.73 | 88.10 ± 63.04 | 8.4 |
Areas under the IOP response versus time curve are presented. AUC0-last = area under the curve for the decrease of IOP (mmHg) vs time (hours). The area was determined relative to the initial baseline at the time of eyedrop instillation until the last IOP measurement time. The AUC0-last presenting IOP-lowering effect (decrease in mmHg vs time as compared to the baseline) of each molecule in pigmented and albino eyes was compared for each molecule with Welch’s (unequal variances) t-test using the SigmaPlot 15.0 program: 1statistically significant P = 0.03 (t = −3.036 with 4.06 degrees of freedom), 2statistically significant P = 0.003 (t = −6.348 with 4.001 degrees of freedom), 3statistically significant P = 0.04 (t = −2.778 with 4.129 degrees of freedom).