Table 5. Exposure of CAI A01 in Albino and Pigmented Iris-Ciliary Body of Rats (AUC) after Instillation of a Single Topical Eye Drop^a.

	AUC0-last ((ng/mg) × h) in albino tissues	AUC0-last ((ng/mg) × h) in pigmented tissue	exposure ratio (AUCpigm/AUCalbino)
total A01	1.37	24.72	18.0
bound A01	0.09	12.73	149.8
unbound A01	1.29	11.98	9.3

^aBound and unbound concentrations were separately quantitated and used for AUC calculations.