Figure 2.

Rational development of potent binders. a) 2D plot analysis of previously identified 15‐LOX‐1 inhibitors, based on lipophilicity (clogP) and shape index, as well as the molecular weight (MW) and the polar surface area. The size and the color of every dot represents the quantity of similar scaffolds and the inhibitory value (nM), respectively. b) Representation of the inhibitory potency of amine (nM), acid (nM) and isocyanide (at 50 μΜ) fragments against 15‐LOX‐1. The active fragments are presented and the common structural component is highlighted. The color gradient represents the inhibitory potency, ranging from high (green) to low (red).