Representative quotes
	The starting point is to try to answer something focused and not broad. So I think that would be key. (Methodologist #5)
	I found it useful limiting the number of potential applications of the test…limiting the number of index steps to assess only in context and setting in use, and also limiting the population to determine the exact intended population and not any other population. (Knowledge user #1)
	It depends on the clinical pathway of the target condition; if, for example, you already know that children are not really infected, then you can start limiting the population. But if you don't know that, I would not limit. So again, I think whether they are unacceptable or not depends on the situation. (Methodologist #7)