Table 2.

Problem distribution of reviewed papers

Problem	Count	Reference
CRISPR arrays	2	[37, 128]
CRISPR loci	2	[137, 157]
CRISPR systems CrRNA	2	[145, 147]
Acr proteins	6	[35, 47, 57, 109, 193, 242]
Aca proteins	1	[216]
CRISPR operons	2	[217, 223]
Cas protein	2	[220, 235]
Off target activity	10	[78, 112, 117, 139, 172, 178, 187, 221, 232, 234, 238]
On target activity	16	[34, 40, 50, 61, 92, 103, 127, 138, 141, 152, 209, 219, 228, 231, 232, 234]
Editable target region	1	[10]
Gene editing outcome prediction	4	[6, 105, 116, 163]
Acr proteins activity	2	[63, 132]