Table 3.
Univariable and multivariable Cox regression analyses for overall survival
| Univariable analysis | Multivariable analysis | |||
|---|---|---|---|---|
| Hazard ratio | P value | Hazard ratio | P value | |
| Age | 1.05 (1.00–1.10) | 0.053 | ||
| Sex | ||||
| Male | 1.00 (Reference) | |||
| Female | 1.01 (0.49–2.08) | 0.979 | ||
| Adjuvant therapy | ||||
| mFOLFIRINOX | 1.00 (Reference) | 1.00 (Reference) | ||
| Other adjuvants | 2.87 (1.22–6.77) | 0.016 | 2.91 (1.24–6.81) | 0.014 |
| Re-staged resectability | ||||
| RPC | 1.00 (Reference) | |||
| BRPC | 2.37 (0.82–6.89) | 0.112 | ||
| LAPC | 4.43 (0.78–25.26) | 0.093 | ||
| Post-treatment CA 19–9 | ||||
| < 37 U/mL | 1.00 (Reference) | 1.00 (Reference) | ||
| ≥ 37 U/mL | 2.29 (1.11–4.73) | 0.026 | 2.39 (1.14–5.03) | 0.021 |
| Tumor size (ypT) | ||||
| < 2 cm | 1.00 (Reference) | |||
| ≥ 2 cm | 2.34 (0.80–6.84) | 0.119 | ||
| LN metastasis (ypN) | ||||
| Negative (N0) | 1.00 (Reference) | 1.00 (Reference) | ||
| Positive (N1 or N2) | 2.42 (1.07–5.49) | 0.034 | 1.93 (0.84–4.41) | 0.121 |
| Resection margin | ||||
| Negative | 1.00 (Reference) | |||
| Positive | 1.17 (0.50–2.75) | 0.713 | ||
| CAP score | ||||
| 1 | 1.00 (Reference) | |||
| 2 | 1.91 (0.25–14.48) | 0.534 | ||
| 3 | 5.78 (0.74–45.35) | 0.095 | ||
Values in parentheses are 95 per cent confidence intervals. Variables with P < 0.05 in univariable analysis were included in the multivariable model
mFOLFIRINOX modified FOLFIRINOX, BRPC borderline resectable pancreatic cancer, LAPC locally advanced pancreatic cancer, RPC resectable pancreatic cancer, CA 19–9 carbohydrate antigen 19–9, CAP score College of American Pathologists score