Table 2.

Univariate Cox analysis of variables in included patients

Variable	OS		CSS
	HR	P	HR	P
Race
White	Reference		Reference
Black	0.951 (0.620–1.459)	0.819	0.977 (0.625–1.527)	0.918
Others	0.738 (0.450–1.212)	0.230	0.820 (0.497–1.350)	0.435
Gender
Female	Reference		Reference
Male	0.916 (0.682–1.230)	0.559	0.942 (0.692–1.281)	0.703
Age(years)	1.027 (1.013–1.040)	< 0.001***	1.024 (1.010–1.038)	< 0.001***
≤ 70	Reference		Reference
> 70	1.51 (1.122–2.032)	0.007**	1.368(1.000–1.870)	0.0497*
Primary site
Head of pancreas	Reference		Reference
Body of pancreas	1.204 (0.728–1.990)	0.469	1.167 (0.687–1.981)	0.568
Tail of pancreas	0.643 (0.401–1.032)	0.067	0.658 (0.405–1.069)	0.091
Others*	1.234 (0.878–1.735)	0.225	1.183 (0.828–1.691)	0.356
Histologic type
Large cell neuroendocrine carcinoma	Reference		Reference
Small cell carcinoma	1.359 (0.991–1.864)	0.057	1.221 (0.883–1.689)	0.228
Tumor size (cm)	1.006 (1–1.013)	0.045*	1.008 (1.001–1.014)	0.021*
≤ 5	Reference		Reference
> 5	1.445 (0.979–2.133)	0.064	1.46 (0.971–2.195)	0.069
Surgery
No	Reference		Reference
Yes	0.347 (0.142–0.850)	0.021*	0.303 (0.112–0.821)	0.019*
Radiotherapy
No	Reference		Reference
Yes	0.588 (0.327–1.059)	0.077	0.585 (0.317–1.081)	0.087
Chemotherapy
No	Reference		Reference
Yes	0.285 (0.210–0.388)	< 0.001***	0.291 (0.211–0.401)	< 0.001***
Brain metastasis
No	Reference		Reference
Yes	1.36 (0.636–2.91)	0.428	1.261 (0.555–2.862)	0.580
Lung metastasis
No	Reference		Reference
Yes	1.481 (0.997–2.201)	0.052	1.394 (0.913–2.128)	0.124
Bone metastasis
No	Reference		Reference
Yes	0.981 (0.620–1.552)	0.933	0.969 (0.598–1.569)	0.897
Diagnose to treatment (months)	0.863 (0.717–1.037)	0.116	0.720 (0.566–0.918)	0.008**

Significantly difference: *P < 0.05; **P < 0.01; ***P < 0.001