Table 1.
Demographics and clinicopathological characteristics of patients
| Clinicopathological characteristics | Noninvasive (AAH + AIS) | Minimally invasive (MIA) | Invasive (IA) | P value (χ2) | P value (Linear correlation) | ||
|---|---|---|---|---|---|---|---|
| N | 258 | 125 (48.4) | 59 (22.9) | 74 (28.7) | |||
| Sex |
Male Female |
106 (41.1) 152 (58.9) |
40 (32.0) 85 (68.0) |
25 (42.4%) 34 (57.6%) |
41 (55.4%) 33 (44.6%) |
0.005** | 0.001*** |
| Age, year |
Median Range |
53 20–77 |
50 20–74 |
53 27–77 |
58 37–74 |
< 0.001*** | < 0.001*** |
| Smoking |
Yes Never |
63 (24.4) 195 (75.6) |
21 (16.8) 104 (83.2) |
10 (16.9) 49 (83.1) |
32 (43.2) 42 (56.8) |
< 0.001*** | < 0.001*** |
| Nodule number |
Single Multiple |
163 (63.2) 95 (36.8) |
84 (67.2) 41 (32.8) |
37 (62.7) 22 (37.3) |
42 (56.8) 32 (43.2) |
0.335 | 0.145 |
| Nodule location |
Left upper lobe Left lower lobe Right upper lobe Right middle lobe Right lower lobe |
75 (29.1) 44 (17.1) 74 (28.7) 17 (6.6) 48 (18.6) |
39 (31.2) 21 (16.8) 35 (28.0) 8 (6.4) 22 (17.6) |
17 (28.8) 9 (15.3) 16 (27.1) 4 (6.8) 13 (22.0) |
19 (25.7) 14 (18.9) 23 (31.1) 5 (6.8) 13 (17.6) |
0.993 | 0.612 |
| Nodule type |
Nonsolid or ground-glass opacity (GGNs) Part-solid (PSNs) Solid or Soft tissue density (SNs) Cystic lesions |
126 (49.2) 81 (31.6) 46 (18.0) 3 (1.2) |
85 (68.5) 31 (25.0) 6 (4.8) 2 (1.6) |
30 (50.8) 22 (37.3) 7 (11.9) 0 |
11 (15.1) 28 (38.4) 33 (45.2) 1 (1.4) |
< 0.001*** | < 0.001*** |
| Lesion diameter (cm) |
≤ 1 1.1–2 |
174 (67.4) 84 (32.6) |
101 (80.8) 24 (19.2) |
49 (83.1) 10 (16.9) |
24 (32.4) 50 (67.6) |
< 0.001*** | < 0.001*** |
| Nodule size (cm) |
≤ 1 1.1–2 2 < |
147 (57.0) 86 (33.3) 25 (9.7) |
89 (71.2) 36 (28.8) 0 |
42 (71.2) 16 (27.1) 1 (1.7) |
16 (21.6) 34 (45.9) 24 (32.4) |
< 0.001*** | < 0.001*** |
AAH atypical adenomatous hyperplasia, AIS adenocarcinoma in situ, IPA invasive pulmonary adenocarcinoma, MIA minimally invasive adenocarcinoma
∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001