Table 2.

Diagnostic efficacy of different markers and combined assay panels in identifying groups 1 and 2

	AUC		Sensitivity% (95% CI)	Specificity% (95% CI)	PPV	NPV
	Value	95% CI
RASSF1A	0.6635	0.5972–0.7299	43.61 (35.48–52.10)	88.0 (81.14–92.59)	0.747	0.586
SHOX2	0.6533	0.5866–0.7200	35.34 (27.73–43.77)	88.0 (81.14–92.59)	0.754	0.558
EGFR	0.6102	0.5413–0.6792	34.59 (27.04–43.00)	88.0 (81.14–92.59)	0.660	0.576
TM (RASSF1A + SHOX2)	0.7011	0.6375–0.7647	43.61 (35.48–52.10)	88.0 (81.14–92.59)	0.738	0.642
			51.88 (43.46–60.20)	80.0 (72.14–86.07)
RASSF1A + EGFR	0.7022	0.6382–0.7662	40.60 (32.63–49.10)	88.0 (81.14–92.59)	0.706	0.697
			52.63 (44.19–60.92)	80.0 (72.14–86.07)
SHOX2 + EGFR	0.6864	0.6216–0.7513	43.61 (35.48–52.10)	88.0 (81.14–92.59)	0.681	0.667
			54.89 (45.67–62.37)	80.0 (72.14–86.07)
TM + EGFR	0.7294	0.6674–0.7913	48.12 (39.80–56.54)	88.0 (81.14–92.59)	0.690	0.748
			60.90 (52.41–68.78)	80.0 (72.14–86.07)