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. 2023 Apr 25;149(11):8557–8571. doi: 10.1007/s00432-023-04745-8

Table 4.

Correlation between EGFR mutation and RASSF1A and SHOX2 methylations

Methylation EGFR mutation P value (Chi-square) Rho (Spearman) P value (Correlation) P value (CMH test)
Mutated (%) Wild type (%)
RASSF1A  +  42 (53.2) 37 (46.8) 0.002 0.196 0.002 0.038
58 (32.4) 121 (67.6)
SHOX2  +  26 (42.6) 35 (57.4) 0.478 0.044 0.480 0.576
74 (37.6) 123 (62.4)

Cochran–Mantel–Haenszel test was used for the correlation analysis after controlling the pathological subtypes as covariates