Table 3.

Impact of dysregulated miRNAs on cellular processes in hyperoxia-exposed animals and cells.

Cell process	Change vs controls	miRNAs	Samples	References
Oxidative stress	↓	miR-425	RLE-6TN	[59]
	↑	miR-34a	mouse lung tissues	[25]
	↑	miR199a	MLECs	[27]
	↑	miR-29a	MLE12	[42]
Inflammation	↑	miR-451	mouse lung tissues	[43]
	↑	miR-421	MLE12	[46]
	↓	miR-214	rat lung tissues	[58]
	↓	miR-876	mouse lung tissues	[26]
Proliferation	↓	miR-206	A549, H441	[60]
	↓	miR-29a	MLE12	[40]
	↑	miR-206	A549, H441	[60]
	↑	miR-34a	MLE12	[25]
	↑	miR-203a	RLE-6TN	[31]
	↓	miR-342	MLE12	[54]
	↑	miR-421	mouse lung tissues, MLE12	[40,41,46]
Apoptosis	↑	miR-29a	MLE12	[42]
	↑	miR-421	mouse lung tissues	[41]
	↑	miR-194	mouse lung tissues, BEAS-2B	[47]
	↓	miR-20b	rat lung tissues, AEC II	[57]
	↓	miR-214	rat primary embryonic type II alveolar epithelial cells	[58]
	↓	miR-425	RLE-6TN	[59]
	↓	miR-21	AEC II	[65]
Senescence	↑	miR-34a	MLE12, SAEC	[66]
	↓	miR-34a	MLE12	[19]
	↑	miR-30a	HPMECs	[51]
Angiogenesis	↓	miR-200a	HUVECs	[53]
	↓	miR-203a	rat lung tissues, RLE-6TN	[31]
	↑	miR-342	mouse lung tissues	[54]
	↓	miR-451	mouse lung tissues, MLECs	[43]

Abbreviations: A549, Human lung adenocarcinoma epithelial cell line, metastatic cells; AEC II, rat primary type II alveolar epithelia cell; BALF, bronchoalveolar lavage fluid; BEAS-2B, human pulmonary bronchial epithelial cells; H441, Human lung adenocarcinoma epithelial cell line, nonmetastatic cells; HPMECs, neonatal human pulmonary microvascular endothelial cells; HUVECs, Human umbilical vein endothelial cells; MLE12, mouse lung epithelial cells; MLECs, murine lung endothelial cells; RLE-6TN, rat type II alveolar epithelial cell; SAEC, human small airway epithelial cells. ↑ : upregulation; ↓ : downregulation on cellular processes by miRNAs.