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. 2024 Jul 10;20(9):2727–2736. doi: 10.4103/NRR.NRR-D-23-01233

Figure 5.

Figure 5

Changes in hippocampal iNOS, IL-1β, and CD206 protein expression and behavioral tests after ERK inhibitor treatment.

(A) Representative western blots and densitometric analysis showing the expression of iNOS, IL-1β, and CD206 in the hippocampus on day 3 after surgery and treatment. (B) Spontaneous alternation (%) and (C) freezing time (%) of each group on day 3 after surgery. (D) Representative western blots and densitometric analysis showing the expression of BDNF and pNR2B in the hippocampus on day 3 after surgery. The experiments were repeated three times. *P < 0.05 (one-way analysis of variance followed by Tukey’s post hoc test). CHI3L1: Chitinase-3–like protein 1; ERK: extracellular signal–regulated kinase; IL-1β: interleukin-1β; iNOS: inducible nitric oxide synthase; PD: ERK inhibitor PD98059; rCLP: recombinant CHI3L1; S: surgery; Veh: vehicle.