Table 2.
Cox-regression analysis of parameters associated with OS and RFS of AML patients
| Factors | OSa) | RFSb) | ||||||
|---|---|---|---|---|---|---|---|---|
| U variate | Multivariate | U variate | Multivariate | |||||
| P | HRc) | 95% CI | P | P | HR | 95% CI | P | |
| Age, years (≤ 60/ > 60) | 0.059 | 2.921 | 1.134–7.526 | 0.026 | 0.021 | 3.260 | 1.302–8.160 | 0.012 |
| Gender(male/female) | 0.743 | – | – | – | 0.887 | – | – | – |
| WBCd) (< 10/ ≥ 1 × 109/L) | 0.862 | – | – | – | 0.994 | – | – | – |
| HGBe) (< 80/ ≥ 80, g/L) | 0.142 | – | – | – | 0.200 | – | – | – |
| PLTf) (< 50/ ≥ 50, × 109/L) | 0.198 | – | – | – | 0.123 | – | – | – |
| Blast in BMg) (< 50%/ ≥ 50%) | 0.400 | – | – | – | 0.483 | – | – | – |
| EIF2S3 expression (high/low) | 0.023 | 0.299 | 0.115–0.772 | 0.013 | 0.011 | 0.277 | 0.108–0.716 | 0.008 |
| Treatment(chemotherapy/transplantation/none) | 0.132 | 0.618 | 0.299–1.281 | 0.196 | 0.030 | 0.717 | 0.370–1.387 | 1.387 |
*P < 0.05, the difference was statistically significant
a) OS overall survival, b) RFS relapse-free survival, c) HR hazard ratio, d) WBC white blood cell, e) HGB hemoglobin, f) PLT Platelets, g) Blast in BM blast percentage in bone marrow