Table 2.
Circulating immune and inflammation-related proteins with statistically significant trends for association with esophageal squamous cell carcinoma
| Proteins (other names) | Quartile | Adjusted odds ratio (95% CI) |
|---|---|---|
| Syntaxin-16 (STX16)* | 1 | 1.0 |
| 2 | 2.49 (0.76–8.19) | |
| 3 | 2.94 (0.87–10.01) | |
| 4 | 5.05 (1.59–16.06) | |
| p trend | 0.008 | |
| Heme oxygenase 1 (HO-1)** | 1 | 1.0 |
| 2 | 0.40 (0.10–1.54) | |
| 3 | 3.52 (1.12–11.05) | |
| 4 | 2.39 (0.74–7.72) | |
| p trend | 0.014 | |
| Cluster of differentiation 40 (CD40, tumor necrosis factor receptor superfamily member 5)** | 1 | 1.0 |
| 2 | 2.71 (0.75–9.79) | |
| 3 | 3.29 (0.92–11.75) | |
| 4 | 5.54 (1.42–21.57) | |
| p trend | 0.018 | |
| Gamma-secretase-activating protein (GSAP)* | 1 | 1.0 |
| 2 | 0.42 (0.13–1.37) | |
| 3 | 1.30 (0.41–4.06) | |
| 4 | 2.59 (0.82–8.21) | |
| p trend | 0.036 |
CI confidence interval
*Biomarker included in the Immuno-oncology panel
**Biomarker included in the Cell Regulation panel