Table 2.

Influence of p21 on cell cycle after irradiation

Experimental material	Treatment	p21 influence on cell cycle after irradiation	Study
Cardiac microvascular endothelial cells	X-ray	G1/S cell cycle arrest increased	Zeng et al. (2020)
HeLa cells	X-ray	Resulted in G2/M arrest	Furusawa et al. (2012)
Human oral cancer cell lines	X-ray	Arrested the cell cycle in the G2/M phase	(Ho et al. (2019)
Nasopharyngeal carcinoma cell line	X-ray	Repression of p21 expression resulted in G1 and G2 arrest decrease	Liu et al. 2006)
Non-small cell lung cancer cell lines	X-ray	Enhancing G2/M arrest	Wang et al. (2017)
Breast cancer lines	X-ray	Resulted in G2/M arrest	Yang et al. (2012)
Human uveal melanoma 92–1 cells	X-ray and Fe ions	Resulted long-term G2 arrest	Zhang et al. (2016)
Normal human foreskin AG1523 diploid fibroblasts	UV irradiation	p21 induced by irradiation bound to CDK2 and CDK4 inhibiting their activity	Poon et al. (1996)
N-TERT keratinocytes	UVB irradiation	Caused G1 arrest	Collier et al. (2018)
C57BL/6 and BALB/c mice, murine colorectal carcinoma cell line CT26 and IEC6	γ-Irradiation from a 137Cs source	Activation of p53/p21 mediated reversible cell cycle arrest	Nag et al. (2019)
Human colon carcinoma cells (HCT116/p21+/+)	γ-Irradiation from a 137Cs source	Inhibition of p21 induced by irradiation resulted in disappearance of G1 phase arrest	Tian et al. (2000)
HCT116 cell line	γ-Irradiation	Wild-type cells were permanently arrested in the G2-M phase, while p21-deficient cells did not occur cycle arrest	Sohn et al. (2006)
MCF-7 and HCT116 cell lines	γ-Irradiation	Irradiation -induced p21 and G2/M arrest	Wendt et al. (2006)
Brain cell PC12	60Co and UVA	Cells stagnated in G1 phase	Liu et al. (2020)
Human epidermoid carcinoma cells A431	Photodynamic therapy	Caused G1/S cell cycle arrest	Ahmad et al. (1998)