Table 6.

Multivariable Cox Proportional Hazards Model for Overall Hepatocellular Carcinoma Mortality (N=78,471)

Characteristics	HR	95% Cl	p-value
Age  20–49 years  50–59 years  60–69 years  ≥70 years	-- 1.16 1.22 1.66	Ref 1.12–1.20 1.17–1.26 1.60–1.72	-- <0.001 <0.001 <0.001
Sex  Female  Male	-- 1.11	Ref 1.09–1.14	-- <0.001
Race/ethnicity  Non-Hispanic White  African American  Hispanic  Asian/Pacific Islander  American Indian/Alaska Native	-- 1.10 0.97 0.83 1.00	Ref 1.07–1.13 0.95–0.99 0.81–0.85 0.93–1.09	-- <0.001 0.008 <0.001 0.908
Geography  Large metro  Medium metro  Small metro  Rural	-- 1.09 1.08 1.06	Ref 1.07–1.11 1.04–1.12 1.02–1.09	-- <0.001 <0.001 0.004
Annual household income  ≥$70,000  $55,000-$69,999  $40,000-$54,999  <$40,000	-- 1.06 1.15 1.25	Ref 1.04–1.08 1.11–1.18 1.17–1.33	-- <0.001 <0.001 <0.001
Interaction Analyses
Race/Income*  High-income Non-Hispanic White  Middle-income Non-Hispanic White  Low-income Non-Hispanic White  High-income African American  Middle-income African American  Low-income African American  High-income Hispanic  Middle-income Hispanic  Low-income Hispanic  High-income Asian/Pacific Islander  Middle-income Asian/Pacific Islander  Low-income Asian/Pacific Islander  High-income American Indian/Alaska Native  Middle-income American Indian/Alaska Native  Low-income American Indian/Alaska Native	-- 1.08 1.22 1.09 1.20 1.44 0.99 1.03 1.05 0.84 0.87 0.52 0.93 1.17	Ref 1.06–1.11 1.13–1.31 1.04–1.13 1.16–1.24 1.27–1.64 0.96–1.02 1.00–1.06 0.86–1.29 0.81–0.86 0.84–0.86 0.17–1.62 0.83–1.05 1.05–1.30	-- <0.001 <0.001 <0.001 <0.001 <0.001 0.487 0.035 0.618 <0.001 <0.001 0.262 0.268 0.004
Race/Geography†  Large metro Non-Hispanic White  Small-medium metro Non-Hispanic White  Rural Non-Hispanic White  Large metro African American  Small-medium metro African American  Rural African American  Large metro Hispanic  Small-medium metro Hispanic  Rural Hispanic  Large metro Asian/Pacific Islander  Small-medium metro Asian/Pacific Islander  Rural Asian/Pacific Islander  Large metro American Indian/Alaska Native  Small-medium American Indian/Alaska Native  Rural American Indian/Alaska Native	-- 1.05 1.03 1.08 1.17 1.16 0.96 1.04 0.94 0.79 1.02 1.07 0.99 1.03 1.11	Ref 1.02–1.08 0.99–1.07 1.05–1.12 1.12–1.23 1.05–1.27 0.94–0.99 1.00–1.08 0.85–1.03 0.77–0.81 0.97–1.07 0.93–1.24 0.88–1.12 0.91–1.18 0.95–1.30	-- <0.001 0.148 <0.001 <0.001 0.003 0.007 0.060 0.179 <0.001 0.523 0.325 0.867 0.635 0.192

^*Adjusted for age, sex, geography, year of diagnosis, number of tumors, stage at diagnosis, and receipt of treatment

^†Adjusted for age, sex, income, year of diagnosis, number of tumors, and stage at diagnosis, and receipt of treatment