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Genomic organization of the WHS region in chromosome 4p16.3. With the exception of the PAC clone 184O23, all the reported probes are cosmids, most of which were used in our analysis for FISH. A contig including all the WHS candidate genes (WHSC2, WHSC1, and LETM1) is indicated. Note that WHSC2 is identified by cosmid 96a2; WHSC1 by cosmids 19h1, 190b4, and, in part, 184d6; and LETM1 by cosmid 75b9 and by PAC clone 184O23. Relevant 4p deletions are indicated (top).
