Skip to main content
. 2025 Jan 24;15:1496735. doi: 10.3389/fonc.2025.1496735

Figure 3.

Figure 3

Histopathological and immunohistochemical findings in primary lung extranodal NK/T-cell lymphoma. (A) H&E staining demonstrates extensive necrosis with a dense infiltrate of atypical lymphoid cells. (B) Height magnification of H&E staining shows the lymphoma is composed of medium-sized cells. These cells exhibit irregularly folded nuclei, and nucleoli are inconspicuous. (C) Immunohistochemical staining for CD56 shows strong membrane positivity in neoplastic cells, confirming NK cell lineage. (D) Immunostaining for CD3 is positive, consistent with the presence of T cells, further supporting the diagnosis of NK/T-cell lymphoma. (E) Ki-67 proliferation index shows a high percentage of positive cells, indicating a highly proliferative tumor with aggressive behavior. (F) EBER in situ hybridization shows positive cells, confirming the presence of EBV infection within these cells. These findings collectively confirm the diagnosis of primary lung ENKTL, characterized by high-grade lymphoid infiltration and strong expression of NK/T-cell markers. EBER, Epstein–Barr virus-encoded RNA; ENKTL, extranodal NK/T-cell lymphoma; H&E, hematoxylin and eosin; NK, natural killer.