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Proportion of affected and unaffected individuals within 549 families with MS grouped by HLA-DR2 genotypes. The data set contained 2,382 individuals comprising 808 patients with MS and 1,574 unaffected family members. A total of 26.9% (n=319) DRX/DRX and 38.7% (n=395) DR2/DRX individuals were affected, in contrast to 52.8% (n=94) DR2/DR2 individuals, demonstrating a dose effect of HLA-DR2 on susceptibility.
