. 2003 Jan 28;72(3):710–716. doi: 10.1086/367781

Table 2.

OR for HLA-DR Genotypes in Patients with MS Compared with Unaffected Family Members^[Note]

		OR (95% CI)
Test Group	Reference^a	All Families	Multicase Only	Singleton Only
DR2/DR2	DRX/DRX	6.7 (4.2–10.7)^b	6.1 (3.4–11.0)^b	7.9 (3.7–17.0)^b
DR2/DRX	DRX/DRX	2.7 (2.1–3.6)^b	2.6 (1.8–3.7)^b	3.0 (2.0–4.5)^b
DR2/DR2	DR2/DRX	2.5 (1.7–3.7)^c	2.4 (1.4–3.9)^d	2.7 (1.4–5.1)^e

Note.— The analyses include all affected and unaffected individuals from families with multicase (n=187) and singleton (n=362) MS (total n=2,382 individuals; n=808 affected and 1,574 unaffected individuals).

The DRX group refers to all other non-DR2 (DRB1*1501–DQB1*0602) alleles. All analyses were performed using conditional logistic regression modeling and controlling for sex as implemented in PROC PHREG (SAS v. 8.2). All individuals were stratified by family for analyses. Unaffected family members included all parents and siblings of affected individuals.

P<10^-6.

P<10^-5.

P<10^-3.

P<.01.