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. 2003 Jan 21;72(3):722–727. doi: 10.1086/367847

Figure 1.

Figure 1

Haplotype analysis of chromosome 3q13-22 STR markers in families with CMT2B. Pedigrees of four families with an ulcero-mutilating phenotype linked to the CMT2B locus: A, Austrian family CMT-140; B, Austrian family CMT-126; C, Scottish family CMT-90; and D, American family CMT-195. Symbols: open diamond = unaffected; filled diamond = affected; half-filled diamond = probably affected (i.e., CMT-126 II-3); slashed diamond = deceased; arrow = recombination; box = disease-associated haplotype. Pedigree structure and sex are disguised to preserve anonymity. The best genetic and physical order of STR markers is according to NCBI (GenBank/LocusLink). The six newly developed STR markers (D3SCMT126A, D3SCMT126B, D3SCMT126C, D3SCMT126D, D3SCMT126F, and D3SCMT126G) are localized between D3S2324 and D3S1587. Genotypes are represented by allele sizes in base pairs, and 0-0 = failed genotype. The RAB7 gene is located on the same contig (NT_005523) as markers D3SCMT126B and D3SCMT126C. For genotyping, fragment analysis was performed on an ABI Prism3700 DNA Analyzer and processed with the ABI GENESCAN 3.5 and GENOTYPER 3.6 software (Perkin Elmer Applied Biosystems).