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. 2003 Jan 29;72(3):733–738. doi: 10.1086/368062

Figure 1.

Figure 1

Localization of the 22q11 breakpoint of the patient with t(17;22). A, Map of the 22q11 breakpoint region. LCR-22s are indicated by boxes. Location of probes used for FISH analysis are indicated by the vertical bars. B, FISH results on metaphase chromosomes of the t(17;22) patient. Both c68a1 (N41, red) and c87f9 (ZNF74, green) are hybridized simultaneously to metaphase chromosomes. As a control, cos82 (22q13, red) was used to mark distal 22q. Signals for c87f9 and cos82 are observed on the der(17) (arrow), whereas the c68a1 signal is observed remaining on the der(22) (arrow head). This indicates that the breakpoint is located between these markers in LCR22B. The other chromosome with signal for all three probes is the normal chromosome 22.