Table 1.

Previously Published Breast and Ovarian Cancer Risks Associated with Mutations in BRCA1 and BRCA2

	Breast Cancer Risk(95% CI) at(%)		Ovarian Cancer Risk(95% CI) at(%)
Family Ascertainmenta	Age 50 Years	Age 70 Years	Age 50 Years	Age 70 Years	Reference
BRCA1:
Multiple-case families with Br/Ov	73 (49–87)	87 (72–95)	29 (16–40)	44 (28–56)	Ford et al. 1994
Multiple-case families with Br/Ov	51	85	23	63	Easton et al. 1995
Multiple-case families with Ov	39	72	17	53	Antoniou et al. 2000
Hospital-based Ov cases	34 (17–60)	50 (26–82)	21 (8–47)	68 (36–94)	Antoniou et al. 2000
Hospital-based Ashkenazi Jewish Br casesb		60			Warner et al. 1999
Hospital-based Ashkenazi Jewish Br casesb		46 (31–80)			Satagopan et al. 2001
Population-based Br cases	32 (2–62)	47 (5–82)	11 (1–74)	36 (4–99)	Anglian Breast Cancer Study Group 2000
Population-based Ov cases	13	30	5.4	15	Risch et al. 2001
BRCA1 and BRCA2:
Population-based Br cases	10 (0–24)	40 (16–64)			Hopper et al. 1999
Unaffected Ashkenazi Jewish womenc	33 (23–44)	56 (40–73)	7 (2–14)	16 (6–28)	Struewing et al. 1997
BRCA2:
Multiple-case families with Br/Ov	28 (9–44)	84 (43–95)	.4 (0–1)	27 (47)	Ford et al. 1998
Multiple-case Ov families	19	71	1	31	Antoniou et al. 2000
Hospital-based Ashkenazi Jewish Br casesd		28			Warner et al. 1999
Hospital-based Ashkenazi Jewish Br casesd		26 (14–50)			Satagopan et al. 2001
Population-based Br casese	17 (9–26)	37 (22–54)			Thorlacius et al. 1998
Population-based Br cases	18 (2–32)	56 (5–80)	3 (0–19)	10 (1–55)	Anglian Breast Cancer Study Group 2000
Population-based Ov cases	3.6	8.8	1.6	4.5	Risch et al. 2001

^aBr = breast cancer; Ov = ovarian cancer

^bCarrying 185delAG and 5382insC.

^cCarrying 185delAG, 5382insC, and 6174delT.

^dCarrying 6174delT.

^eCarrying 999del5.