Table 5.
RRs for Mutation Carriers, as Compared to Baseline, for Models Allowing for Center, Type-of-Index-Case, and Year-of-Birth Effects[Note]
|
RR (95% Floated CI) for Carriers of Mutations in |
||||
|
BRCA1 (P=.32) |
BRCA2 (P=.13) |
|||
| Center | Breast Cancer | Ovarian Cancer | Breast Cancer | Ovarian Cancer |
| United Kingdoma | 1.0 (.55–1.8) | 1.0 (.41–2.4) | 1.0 (.69–1.4) | 1.0 (.33–3.1) |
| Canada | .51 (.36–.71) | .34 (.19–.59) | .53 (.30–1.0) | 3.1 (1.3–7.1) |
| Poland | .47 (.28–.78) | .40 (.18–.90) | … | … |
| Iceland | … | … | 1.0 (.69–1.4) | 1.0 (.33–3.1) |
| Other | .69 (.44–1.1) | .52 (.25–1.1) | 1.4 (.77–2.6) | 4.2 (1.2–14) |
|
RR (95% Floated CI) for Carriers of Mutations in |
||||
|
BRCA1 (P=.015) |
BRCA2 (P=.01) |
|||
| Type of Index Case | Breast Cancer | Ovarian Cancer | Breast Cancer | Ovarian Cancer |
| Breast cancer at ⩾35 yearsa | 1.0 (.68–1.5) | 1.0 (.53–1.9) | 1.0 (.68–1.5) | 1.0 (.42–2.4) |
| Breast cancer at <35 years | 2.2 (1.4–3.3) | 1.8 (.82–4.0) | 1.2 (.57–2.5) | 14 (3.8–53) |
| Male breast cancer | … | … | 1.3 (.65–2.7) | 1.8 (.92–3.6) |
| Ovarian cancer | .83 (.59–1.2) | 1.1 (.69–1.8) | .45 (.23–.89) | 6.5 (2.1–21) |
|
RR (95% Floated CI) for Carriers of Mutations in |
||||
|
BRCA1 (P=.00001) |
BRCA2 (P=.16) |
|||
| Year of Birth | Breast Cancer | Ovarian Cancer | Breast Cancer | Ovarian Cancer |
| Before 1920a | 1.0 (.53–1.9) | 1.0 (.27–3.7) | 1.0 (.60–1.7) | … |
| 1920–39 | 2.7 (1.9–3.8) | 12 (7.3–18) | 1.2 (.71–1.9) | … |
| 1940–59 | 3.7 (2.6–5.1) | 9.5 (4.9–19) | 2.1 (1.2–3.6) | … |
| 1960 onward | 7.7 (2.6–23) | … | 4.8 (1.0–23) | … |
Note.— P values are from comparison of the fitted model with that of the basic model. Age-specific RRs for each of these models are not shown but in all cases were similar to the estimates for the basic model (table 4).
a
Baseline category.