Table 1.

ASP Families Included in Genomewide Scan

	Wave 1a	Wave 2	Combinedb
No. of families with:
Two affected sibs	96	86	180
Three affected sibs	6	12	18
Four affected sibs	2	3	6
Total	104	101	204
Total independent ASPsc	114	119	234
Total ASPsd	126	140e	270

^aSubset of families reported elsewhere (Fisher et al. 2002).

^bThe number of possible ASPs in the combined set reflects the sum of possible pairs in wave 1 and wave 2, plus an additional ASP created from the addition of 2 affected siblings from a wave 1 family that were collected after wave 1 was completed. The combined set includes this ASP, while wave 2 does not, so that the families in wave 1 and wave 2 are completely independent. Thus, in the combined data set there is 1 additional independent ASP and 4 additional total ASPs over and above the sum of wave 1 and wave 2.

^cA family with n sibs contributes n−1 independent pairs.

^dA family with n sibs contributes n(n−1)/2 possible pairs.

^eOf these 140 ASPs, 107 were included in a previous analysis of chromosome 16p (Smalley et al. 2002).