TABLE 2.

Non-histone lactylation in brain diseases.

Disease	Site of lactylation	Mechanism	Writer/Eraser	Ref
Ischemic stroke	ARF1 K73	Exacerbated brain injury by limiting mitochondrial transfer	Unknown	Zhou et al. (2024a)
High-altitude cerebral edema	NuRD complex	Increased inflammation response under hypoxic conditions	Unknown	Jiang et al. (2024a)
Ocular neovascularization	YY1 K183	Enhanced FGF2 transcription and promoted angiogenesis	p300	Wang et al. (2023a)
Hypoxic-ischemic encephalopathy	cGAS K162	Promoted the transformation of microglia into M1 type	Unknown	Wang et al. (2024c)
Chronic restraint stress	SNAP91 K885	Promoted the formation of synaptic structures and neuronal activity	Unknown	Yan et al. (2024a)
Alzheimer’s disease	tau K677	Promoted ferroptosis, decreased memory, and increased neuronal damage	Unknown	An et al. (2024)