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. 2003 Apr 8;72(5):1315–1322. doi: 10.1086/375122

Figure 1.

Figure 1

Haplotypes of markers showing linkage to DFNB37 at 6q13 for three families segregating profound, sensorineural, recessive hearing loss. Affected individual IV:17 in family PKDF10 provided the proximal recombination breakpoint at marker D6S1282 (82.59 cM). The distal recombination is provided by affected individual IV:10 of family PKDF71 at marker D6S1031 (88.63 cM). National Institutes of Health (OH93-N-016) and National Centre of Excellence in Molecular Biology (CEMB) institutional review board approval and written informed consent were obtained from all participating subjects. DNA was extracted from either peripheral blood samples or buccal swabs and was amplified using fluorescent-labeled primers for STR markers linked to reported nonsyndromic recessive deafness (DFNB) loci. Amplimers were visualized by gel electrophoresis on ABI 377 DNA sequencers, and genotypes were determined using Genescan and Genotyper software (Applied Biosystems). The genetic linkage distances are from the Center for Medical Genetics Web server.