Table 1.
SNPs Used in this Study, and Allele Frequencies in Patients with T1D and Controls
|
Allele |
Frequency in(%) |
|||||
| Geneand SNP | Reference | Variant | Controls | Patients | Pa | ORb (95% CI) |
| IL4R: | ||||||
| 5′ (−3223) | C | T | 41.9 | 51.1 | .10 | 1.45 (.96–2.19) |
| 5′ (−1914) | C | T | 44.1 | 42.7 | .86 | 1.06 (.70–1.60) |
| I50V | A | G | 44.1 | 53.9 | .06 | 1.48 (.98–2.23) |
| N142N | C | G | 1.1 | 0 | .17 | .52 (.00–2.13) |
| E375A | A | C | 20.7 | 11.7 | .02 | .50 (.28–.90) |
| L389L | G | T | 17.6 | 6.7 | .001 | .34 (.17–.67) |
| C406R | T | C | 19.1 | 11.7 | .05 | .56 (.31–.99) |
| S478P | T | C | 18.6 | 11.7 | .06 | .58 (.32–1.04) |
| Q551R | A | G | 27.7 | 23.3 | .34 | .80 (.50–1.27) |
| S761P | T | C | 100.0 | 100.0 | … | … |
| IL4: | ||||||
| 5′ (−524) | T | C | 30.9 | 34.4 | .46 | 1.18 (.76–1.82) |
| IL13: | ||||||
| 5′ (−1512) | A | C | 30.6 | 41.0 | .05 | 1.58 (1.03–2.42) |
| 5′ (−1112) | C | T | 23.1 | 30.9 | .12 | 1.49 (.94–2.37) |
| Intron 3 | C | T | 40.4 | 45.6 | .32 | 1.23 (.82–1.86) |
| R110Q | G | A | 39.9 | 46.1 | .23 | 1.29 (.85–1.95) |
a
Differences in reference allele frequencies between cases and controls were tested using a χ2 test. Values in boldface italic type are nominally significant P values (P<.05).
b
ORs refer to the variant allele. Where the frequency in patients was 0, the OR has been computed under the assumption that a single patient sample carried the variant allele.