Table 5.

Estimated IL4 and IL13 Haplotype Frequencies in Patients with T1D and Controls, for Five SNPs on Chromosome 5q31

	Frequency in %(SD)b in
Five-SNPHaplotypea	Controls(N=188)	Patients(N=176)d	ORc	P
CACCA	4.1 (1.3)	3.5 (1.7)	.84
CACCG	8.9 (2.2)	10.6 (2.9)	1.21
CACTA	1.3 (1.1)	3.0 (1.8)	2.26
CCCCG	1.5 (1.0)	.9 (.9)	.61
CCTCG	1.1 (.9)	5.5 (2.3)	5.19	.02
CCTTA	12.6 (2.4)	9.3 (2.0)	.71
TACCG	33.6 (3.8)	21.9 (3.9)	.55	.03
TACTA	16.4 (3.3)	16.3 (3.0)	.99
TACTG	5.0 (1.7)	3.2 (1.4)	.62
TCCCG	4.6 (1.8)	9.8 (2.9)	2.23	.06
TCCTA	1.3 (1.1)	0	.42
TCTCG	5.3 (2.4)	1.7 (1.2)	.31	.07
TCTTA	4.1 (2.1)	12.8 (2.2)	3.47	.004
Others	0	1.7
Total (12 df)				.001

^aIn the table and text, the haplotypes are designated with the SNPs in the following order: IL4 −524, IL13 −1512, IL13 −1112, IL13 intron 3, and IL13 110. The physical order of the SNPs on 5q31 is IL13 −1512, IL13 −1112, IL13 intron 3, IL13 110, IL4 −524. Of the 17 inferred five-SNP haplotypes, only those with an estimated frequency of >1% are shown.

^bThe SD was computed using 100 bootstrap replicates.

^cWhere the frequency in patients was 0, the ORs have been computed under the assumption that a single patient sample carried the haplotype.

^dN is reduced because of missing genotypes.