Table 5.

Sample Sizes Required for the Four Genetic Models in Table 3, at Significance Level 0.01 and 80% Power, Using Two Haplotype Blocks H₁, l=2, and H₂, r=4^[Note]

	Required Sample Size
	T=20			T=30			T=40			T=50			T=60
Model Typeand PD	TC	TH	TG	TC	TH	TG	TC	TH	TG	TC	TH	TG	TC	TH	TG
Heterogeneous recessive:
.05	2,296	3,005	2,145	2,534	3,297	2,455	2,798	3,619	2,806	3,088	3,976	3,202	3,409	4,369	3,650
.10	193	279	241	213	303	271	235	329	303	258	358	339	285	390	379
.15	57	85	82	62	92	92	68	99	102	75	107	113	83	116	125
Heterogeneous dominant:
.05	45	47	60	50	53	67	55	59	75	60	65	84	66	73	94
.10	26	24	29	29	27	33	32	30	38	35	34	43	39	38	48
.15	19	15	17	21	17	21	23	20	24	26	23	28	28	26	32
Additive:
.05	22	18	21	25	21	24	27	24	28	30	27	32	33	31	37
.10	20	16	18	22	18	21	24	21	24	27	24	28	29	27	32
.15	18	13	15	20	16	18	22	18	21	24	20	24	26	23	28
Multiplicative:
.05	29	34	47	32	38	51	35	41	56	38	46	62	42	50	68
.10	15	17	23	17	19	25	19	21	28	21	23	31	23	25	34
.15	12	11	15	13	13	17	14	14	19	15	16	22	17	18	24

Note.— Data shown are for P(H₁₁)=P(H₁₂)=0.5, P(H₂₁)=P(H₂₂)=P(H₂₃)=P(H₂₄)=0.25, Δ_H11H21=P(H₁₁H₂₁)-P(H₁₁)P(H₂₁)=0.075, Δ_H11H22=P(H₁₁H₂₂)-P(H₁₁)P(H₂₂)=0.075, Δ_H11H23=P(H₁₁H₂₃)-P(H₁₁)P(H₂₃)=-0.075, Δ_H11H24=P(H₁₁H₂₄)-P(H₁₁)P(H₂₄)=-0.075, and θ₁=θ₂=0.005.