Table 2.
Clinical Summary
|
Affected Subjects (%) |
||
| Condition | MainGroupa(n = 20) | AdditionalGroupb(n = 6) |
| Reported symptom: | ||
| Gait difficulties | 95 | 83 |
| Leg weakness | 55 | 55 |
| Leg pain | 35 | 50 |
| Leg numbness | 35 | 33 |
| Deterioration of fine motor skills | 90 | 83 |
| Significant writing impairment | 95 | 83 |
| Clinical findingc: | ||
| Cerebellar ataxia: | ||
| Dysarthria | 78 | … |
| Dysmetria | 93 | … |
| Postural and gait abnormalitiesc | 86 | … |
| Tremor: | ||
| Intention | 70 | 83 |
| Resting alone | 10 | 17 |
| Combined (frequency 3–5 Hz) | 30 | 17 |
| Parkinsonian symptomd: | ||
| Mild bradykinesia | 57 | … |
| Mild rigidity | ||
| Upper extremity | 71 | … |
| Lower extremity | 35 | |
| Cogwheeling | 5 | … |
| Neuropathy below the kneee | 60 | 30 |
| Muscle testing: | ||
| Proximal lower limb <5 | 30 | … |
| Distal lower limb <5 | 10 | … |
| Other medical problems (n = 20): | ||
| Urinary incontinence | 55 | 17 |
| Bowel incontinence | 30 | 0 |
| Impotence | 80 | 50 |
| Heart diseasef | 55 | 50 |
| Hypertension | 50 | 50 |
a
Patients meeting both the radiological criteria and at least one clinical criterion.
b
Patients not having MRIs (n=5) or not meeting radiological criteria (n=1).
c
Patients were required to have a score of at least one on the items of the ICARS referred to for each symptom. Results were obtained on 14 videotaped patients.
d
Patients were required to have a score of at least one on the items of the UPDRS referred to for each symptom. Results were obtained on 14 videotaped patients.
e
Neuropathy was identified clinically by impaired toe position or absence of pinprick or vibration sensation.
f
History of ischemia related to congestive heart failure.