Table 1.

Case-Control Analysis of Single SNPs

				Frequency in
Markera	Distanceb(bp)	Location	Allele	EJM1+	Control	OR (95% CI)c
rs11244	0	HLA-DOB	C/t	.82	.75	1.51 (.61–3.68)
rs241441	5,070	ABCB3	C/t	.40	.37	1.15 (.56–2.36)
rs1057141	37,989	ABCB2	G/a	.85	.84	1.09 (.41–2.85)
rs1044244	44,329	PSMB9	T/c	.28	.26	1.08 (.49–2.38)
rs241412	80,879	…	T/g	.43	.34	1.44 (.70–2.97)
rs10751	121,762	HLA-DMB	T/c	.25	.13	2.14 (.90–5.08)
rs2071556	123,780	HLA-DMB	C/a	.55	.36	2.19 (1.07–4.50)
rs206787	162,081	BRD2 promoter	T/a	.53	.33	2.21 (1.08–4.52)
rs3918149	162,216	BRD2 promoter	T/c	.29	.13	2.80 (1.19–6.64)
rs620202	161,048	BRD2 intron 1	G/t	.85	.72	2.16 (.85–5.46)
rs516535	161,524	BRD2 exon 2	C/t	.48	.31	2.05 (1.00–4.22)
rs635688	162,370	BRD2 intron 2	T/c	.53	.34	2.16 (1.05–4.42)
rs2066741	163,304	BRD2 intron 5	T/c	.68	.45	2.51 (1.20–5.24)
rs206781	165,351	BRD2 exon 9	T/c	.70	.65	1.27 (.59–2.69)
rs206777	171,733	…	C/t	.50	.30	2.29 (1.11–4.71)
rs497058	176,049	…	T/c	.51	.34	2.08 (1.01–4.28)
rs1044429	191,853	…	C/t	.85	.81	1.33 (.51–3.44)
rs2581	193,612	HLA-DNA	T/g	.43	.33	1.48 (.72–3.05)
rs365066	194,349	HLA-DNA	T/c	.40	.33	1.35 (.65–2.80)
rs375256	195,031	HLA-DNA	T/c	.79	.75	1.22 (.50–2.99)

^aMarkers are listed in order from DQ to DP.

^bDistances are measured from the first SNP marker, rs11244.

^cStatistically significant associations are underlined. These associated SNPs span the HLA-DMB gene, the BRD2 (RING3) gene, and promoter region.