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Pedigree drawing of families 1 and 2. Affected individuals are indicated by blackened diamonds. The informative marker alleles are shown. All inferred haplotypes reconstructed (in brackets) were done on the basis of minimal recombination. A hatched bar indicates the disease haplotype. Information is shown only for relevant individuals. The sex of all individuals has been disguised, and unaffected at-risk individuals have been omitted to preserve confidentiality.
